endometriosis

Endometriosis is a common chronic inflammatory condition where cells similar to the lining of the uterus (called the endometrium) grows outside the uterus itself. Endometriosis can be found in various locations within the pelvic region (including the reproductive organs). It can also be found in other parts of the body, such as the bowel and bladder, and as far away as the brain and lungs. Here are some key points about endometriosis:

  • 1.      Location and Growth:

    • The tissue resembling the uterine lining can grow in places such as the ovaries, fallopian tubes, and the lining of the pelvis.

    • In rare cases, endometriosis growths may extend beyond the pelvic area.

  • 2.      Menstrual Cycle Impact:

    • Similar to the inner lining of the uterus, endometriosis tissue thickens, breaks down, and bleeds during each menstrual cycle.

    • However, unlike the normal uterine lining, this tissue grows in areas where it doesn’t belong and remains in the body.

  • 3.      Symptoms:

    • The primary symptom of endometriosis is pelvic pain, which often intensifies during menstrual periods.

    • Other common symptoms include:

      • Painful periods (dysmenorrhea): Severe cramping during menstruation.

      • Pain during or after sex.

      • Pain with bowel movements or urination (especially during periods).

      • Excessive bleeding (heavy menstrual periods or bleeding between periods).

      • Infertility: Some discover endometriosis during infertility tests.

      • Additional symptoms may include fatigue, diarrhea, constipation, bloating, or nausea.

  • 4.      Severity and Symptoms:

    • The severity of pain does not always correlate with the extent of endometriosis growths.

    • Some individuals with endometriosis may experience significant pain even with minimal tissue, while others may have extensive tissue with little or no pain.

    • Occasionally, endometriosis remains asymptomatic until fertility issues arise or during unrelated surgeries.

As there is no known cause yet for endometriosis, there are some working theories as to why it occurs. There is ongoing discussion and research about how hormones impact endometriosis. Let’s explore how hormones may impact this condition, and emerging potential treatment strategies:

1.      Oestrogen Receptors (ER):

2.      Endometriosis and Oestrogen:

    • Oestrogen-Dependent: Endometriosis occurs due to the presence and growth of endometrial-like tissue outside the uterus.

    • Ectopic Tissue Response: The ectopic tissue responds to hormonal changes, leading to inflammation and pain.

3.      Treatment Strategies:

In summary, oestrogen plays a pivotal role in endometriosis, affecting tissue growth and inflammation. Research continues to uncover insights for better treatment strategies to improve the quality of life for those with endometriosis. Endometriosis is a long-term condition, but with proper management, individuals can take control of their health and minimize complications.